Asante Kotoko host Berekum Chelsea at the Baba Yara Sports Stadium on matchday 21 of the Ghana Premier League.
Kotoko are on an eight-game winning streak at home, with their last home defeat dating back to November 12, when they lost 1-2 to Nations FC.
The Porcupines have not lost a game at the Baba Yara Sports Stadium since returning to the venue in December 2024.
Kotoko are the favorites as they face Chelsea, who have lost all of their last four away games.
However, the visitors will draw inspiration from their 1-0 win over Bechem United at the Baba Yara Stadium in the MTN FA Cup quarter-finals.
The reverse fixture between the two sides ended in a one-all stalemate.
While a win would send Kotoko back to the top of the table, a victory for Chelsea would end their away losing streak and close the gap on the top four.
Asante Kotoko, who are second on the table with 42 points, trail Bibiani Gold Stars by two points, while Berekum Chelsea occupy 8th position with 32 points.
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Meanwhile, watch as Ghanaians applaud Black Stars for excellent performances against Chad, Madagascar