Some 1.5 million Palestinians are believed to be in Rafah, seeking refuge from Israeli combat operations in the rest of the Gaza Strip. Most of them are living in tents.
In a social media post, Mr Cameron said he was “deeply concerned about the prospect of a military offensive in Rafah.
“The priority must be an immediate pause in the fighting to get aid in and hostages out, then progress towards a sustainable, permanent ceasefire.”
Meanwhile, Ms Bruins Slot described the situation in Rafah as “very worrying”.
“Many civilians in Gaza have fled south. Hard to see how large-scale military operations in such a densely populated area would not lead to many civilian casualties and a bigger humanitarian catastrophe. This is unjustifiable,” she added.
Also on Saturday, the Saudi foreign ministry issued a statement that warned against “targeting the city of Rafah in the Gaza Strip, which is the last resort for hundreds of thousands of civilians forced by the brutal Israeli aggression to flee”.
The ministry also repeated its “demand for an immediate ceasefire”.
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